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What Anti-Aging Treatments Actually Work?
Anti-aging science is reaching humans. This website allows to collectively assess now (not in 30 years) and in humans (not only mice or monkeys) what interventions work. This, by combining our experiences, using biomarkers of aging, questionnaires and deriving statistics.
COVID-19: what treatments actually work? In order to collectively find out, please send this to your contacts bearing covid symptoms: http://TIMExtension.com#covid

 
 
 

About TIMExtension

TIMExtension - Start here!

An anti-aging testing platform... for all!
For simplicity we start with capers, strawberries and long peper.
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Scientific and advisory board

Aubrey de Grey, PhD
Famous scientist and advocate for anti-aging medicines. Chief Scientific Officer of the SENS Research Foundation, major initiator and coordinator of the ongoing movement for anti-aging biomedical developments worldwide.
Brian Kennedy, PhD
Scientist and advocate for healthy aging solutions. Notably, former President of the Buck Institute for Research and Aging in California and current head of the Centre for Healthy Aging Lab in Singapore.
Josh Mitteldorf, PhD
Scientist and famous for his blog Aging-Matters - Playing the Game for a Longer Life. Notably, chief scientific officier of data-beta, an anti-aging clinical trial that searches for synergistic compounds.
Paul Spiegel
Attorney specialized in business law and longevity medicine, board member of major longevity organizations, Honorary Consul for the Republic of San Marino, he has lived in Europe, Asia and the Americas and advises longevity companies throughout the world.
James P Watson, MD PhD
Principal Investigator, Clinical Faculty member of the David Geffen School of Medicine at the University of California Los Angeles. Combines biology of aging and medical views, notably known for his blog Anti-aging Firewalls with Vince Giuliano.
Nickolay Kryuchkov, PhD
Founder and CEO of the Contract Research Organization Clinical Excellence Group (CEG), expert in pharmaceutical R&D, clinical trials and regulatory affairs, researcher in immunology, public health and data science.

 

Founders

The Wright Brothers were the first to control the flight with an engine and eventually changed the world forever. They were just 2 brothers dedicated to their mission without money, just methodology.
 
We were inspired by them to create TIMExtension to help humanity live long and healthy lives. However, we are far from alone. Together with a vibrant community, we want to slow down the process of aging, that causes a lot of suffering, to stop it and even reverse it. With your help we will test and measure different food and molecules to see what really works and spread it around the world at an affordable price.
 
We set a precise and long term strategy to achieve this vision. It starts with a simple "home-made" approach where we mix food (capers, strawberries, long pepper), we mail it to you and we keep some contact with you. In parallel and gradually, we industrialize the platform and get adequate regulatory agreements to test both anti-aging food and anti-aging pharma products. On the long run, we hope to continuously optimize human health and longevity, at minimal effort and maximal enjoyment of added years for all.
 
Harold Knoll
Serial entrepreneur and anti-aging doer, among other things
Edouard Debonneuil, PhD
Scientist and advocate for anti-aging solutions. Codirector of the International Longevity Alliance, among other things

 

Contact

Phone: +336 1451 3070
Email: life@life-xl.com

Contact

Phone: +336 1451 3070
Email: life@life-xl.com

 
 

Anti-aging interventions

Selected interventions

These interventions were presented to the board and we exchange with the board to remove or adjust them as adequate. You may buy these interventions with or without following the associated collective instructions that include the filling of questionnaires as well as physical tests done at home. Please note that following the collective instructions is i) considerably better from a scientific point of view ii) at a non negligible cost:to buy for yourself only, not buy two interventions with a common ingredient, to validate your identify (this is done a bit later), to take and potentially buy health measures before and after (eg medical lab tests near your home or at home), and to report any interruption or non respect of the collective instructions.

Special

This section is... not really about interventions, but about things that are so important to our heart or so close to interventions that we couldn't not show them first!
Therapies against COVID-19
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Which putative treatments actually work against COVID-19 ? Given the emergency and uncertainty, we try to use Life-XL in a way to potentially found out. If we fail to find anything, at least we will have tried.
- If you have or have had COVID-19 symptoms, whether or not you took treatements (both 'arms' are needed for statistical comparisons), A) If you are registered click on the button on the right to start now. B) Otherwise we do a fast track process: drop your email here above and we send you an email to start reporting symptoms -and treatments if any- as soon as tomorrow.
- If you know people with COVID-19 symptoms, have them contribute (drop email at https://life-xl.com#start).
 
NB1: if you are in the USA, this Coronavirus Self-Checker can help you get appropriate care
NB2: we do not advise treatments, please ask a doctor for that - here below for example; we here act as observers and statisticians.
NB3: the statistics will be displayed on Life-XL with adequate care; for several reasons it can not have the value of a clinical trial but it may provide interesting signals.
NB4: we make this totally free

Senofood

Some food was found to contain high amounts of senolytic molecules - these molecules help your body get rid of longstanding senescent cells, like in infants and young adults, to facilitate the renewal of tissues.
Freeze-dried Strawberry powder vs freeze-dried Peach powder.
10 deserts over 2 consecutives weeks, measures over 3 consecutive week-ends
- €150 EUR
€ 150 EUR

 
In order to start Life-XL, we search for the most beneficial food according to clinical trials and this is how we try to compare benefits of strawberries and peaches, two special fruits for health (compared to others we looked at). We put them in dried-frozen powder form so that you do not have variations voer the year, and so that enough content (/fisetin) is taken. Everyone will take the two products but not in the same order: one group will start with strawberries and continue with peaches, the other group will start with peaches and continue with strawberries.

Limits:
- Do not take this if you are allergic to strawberries or peaches or if you are diabetic (high content of fructose). If you have a doubt, stop immediately taking the product and ask your medical doctor.
- To contribute to the scientific experiment, measures of inflammation markers are needed in each of the 3 week-ends. You can either do in a medical lab near your home or do at home but at a cost of about 300 Euros (3 time points). You may buy the product without participating in the collective experiment, but it has less scientific value.
- This collective experiment may or may not yield adequate scientific results.

Concretely, participants will test themselves in a week-end, then take the first received product as a desert in the next 5 week-days, then test themselves again in the week-end, then take the second received product as a desert in the next 5 week-days, then test themselves again in the week-end. The two fruits are served in freeze-dried powder, to mix with water before eating. This conserves most of the dietary value of the fruits and allows us to send them in zip bags that arrive directly in your mailbox.

Research suggests that strawberries

  • contain high amounts of fisetin, a senolytic molecule
  • protect from cancers, in clinical trials
  • reduce inflammation, in clinical trials.
  • Fisetin was found to extend the lifespan of mice.

Research suggests that peaches

  • inhibit the oxydation of bad cholesterol, reduce the creation of arterial plaques and consequently reduce cardiovar diseases
  • reduces cancer risks thanks to its carotenoids (beta-cryptoxanthin, beta-caroten, lutein and zeaxanthin) and phenols. Peaches were notably found to reduce breast and colon cancer risks.
  • Peaches are diuretic reduces kidney and bladder risks. Peaches contain much vitamin C and provitamins A.
The reason why this methodological approach would make sense is that we do not expect the same effects and that we expect some effects to be short-term, that is, measurable following one week.

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Strawberries AND peaches: the mix! Another scientific approach
5 deserts in one week. Measures over 2 consecutive week-ends
- €100 EUR
€ 100 EUR

 
Similar but instead of having "group A versus group B" everyone will receive a mix of the two powders... everyone with a different percentage! Everyone will receive at least 10% strawberry powder and at least 10% peach powder, without knowing what does is which.

After a few dozen persons finish the experiment, we will make mathematical regressions of results over the percentage of peaches (/strawberries) and see if we can have dose-response curves of the effects of strawberries and of peaches! We will publish the results here and email them to the participants.

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Strawberry ONLY! - €75 EUR
€ 75 EUR

 
Just to have your daily dose of Fisetin (during 5 consecutive days)

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Coming soon: senofood combo
Not available yet

 
We are currently trying various preparations. We mix
  • strawberries, that contain high amounts of quercetin
  • capers, that contain high amounts of quercetin
  • long pepper, that contains high amounts of piperlongumine
  • curcuma, that contains high amounts of curcumin
The goal is to combine these various senolytic molecules to hopefully have benefits of the same type as those for example observed with the combination of dasatinib and quercetin.

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Physical activity

Biking while working and charging your computer
Not available yet

 
Coming soon. Out of many good ways to do physical activity we like this one because your efforts are driven and somewhat 'standardized' by the motivation to recharge your computer by pedaling.

Main limits:
- it requires to have 15 cm space between your knees and your desk.
- this typically brings heart rate from 60 at rest to 120 and makes you warm in 10-15 minutes. If you have a doubt on whether your heart/physical condition allows you to do it, please consult your medical doctor
- it is better to nail the engine on a piece of wood on the floor so that the engine doesn't flip during the exercice.

Clinical studies found that pedaling at work not only improves health but also work-related skills such as attention and also attention to others.

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Coming soon : extracts from plants

D-Limonene
Not available yet

 
Coming soon. Extracted from orange peels, D-limonene has anti-inflammatory properties without the traditional side-effects of anti-inflammatory molecules. A clinical trial (RISTOMED, 1 2) found that it improved health overall

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Later : repurposed medicines

These medicines have been used for long on millions of persons, with therefore a high track record on their safety. They were not designed to be anti-aging, yet empirical studies suggest that they are. We are currently investigating how to get the adequate authorisations, would you have some expertise on the matter please don't hesitate to suggest in the form below
Metformin
Not available yet

 
Not sold here at this stage. The toxicity of metformin is extremely low under medical control, however the lifespan effect on lab animals is small and metformin seems to reduce the benefits of physical activity.

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Rapamycin
Not available yet

 
Not sold here at this stage. We are working on authorisations. The lifespan impact of rapamycin on lab animal is greater than that of metformin, however the toxicity of rapamycin is far from negligible at the thought doses.

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Call a medical doctor

Please discuss with your medical doctor any intervention. You may use one of the following services to be followed by a medical doctor.
AMWELL
Not available yet

 
WARNING
We remind you to consult a medical doctor when taking a drug with a prescription.
This is the reason why we suggest you telemedecine platforms.
https://business.amwell.com/
DOCTOR ON DEMAND
Not available yet

 
https://www.doctorondemand.com/
MD LIVE
Not available yet

 
https://www.mdlive.com/
POLYCOM
Not available yet

 
https://www.polycom.com/.html?ss=false

 

Interventions proposed by visitors

Warning: these interventions were proposed by visitors of TIMExtension.com, they were NOT discussed with the board.

 
 

Suggest an intervention

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Aging biomarkers / Health diagnostics

Please note that many of these tests only provide measures at one point in time; for these, if your goal is to monitor the effect of an intervention then 2 or more units need to be bought depending on the intervention.We sell the tests at the price at which they are found online - by buying them here you additionnally benefit from the TIMExtension framework to follow health parameters in relation with interventions and allow statistics towards always improved anti-aging solutions.

Selected health diagnostics

Arterial stiffness

Cardiovascular issues are the main cause of death. Arterial stiffness is a clear marker for cardiovascular issues, and it can be improved with lifestyle choices.
iHeart Internal Age - 195 USD
€ 185 EUR

 
The device simply clips on your finger, measures your "iHeart Internal Age" based on your aortic stiffness in 30 seconds, it can be used anytime you want and for up to 5 persons. The iHeart device measures Aortic Pulse Wave Velocity to determine Internal Age. Aortic Pulse Wave Velocity (AoPWV) is the gold standard of Aortic Stiffness measurement. Aortic Stiffness has been proven in a wealth of scientific literature to be a marker of risk of developing heart disease, dementia, and risk of death from all causes, but it is reversible with positive lifestyle choices such as increased movement, improved diet, and lowered stress.

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DNA methylation clocks

As we age our DNA gradually undergoes modifications: aside from changes of "letters" (mutations), the surrounding chemical structure, notably the "methylation" of the DNA. It was found that some methylation patterns of the DNA white blood cells are strong predictors of mortality and morbidity, smoking and various other factors. This suggests that interventions that reverse some of these methylation patterns are likely to improve health and extend lifespan.
Biological age epigenetic profile, and DNA health profile - by Muhdo - £199.99 GBP
€ 280 EUR

 
Based on saliva. Epigenetic tests allow you to track modifications in your body at a genetic level and how your lifestyle and environment are effecting it. With Life-XL experiments, this test will help you track improvements in your biological age. All it takes is a sample of your saliva to take control of your DNA and your health!

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Biological age - by MyDNAge - 299 USD
€ 285 EUR

 
Based on blood and on Dr. Horvath's epigenetic age clock. "You can't change your genes, but you can change how your genes behave through epigenetics" The majority of the DNA is extracted from the white blood cells, meaning it measures the overall immunity of the body. This test will allow you to track modifications in your biological age after the experiment you conduct on Life-XL

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Biological age - by MyDNAge - 299 USD
€ 285 EUR

 
Based on urine and on Dr. Horvath's epigenetic age clock. "You can't change your genes, but you can change how your genes behave through epigenetics" This test measures the overall urinary tract health since the DNA extracted from the urine sample comes from the organs encompassing the urinary system. This test will allow you to track modifications in your biological age after the experiment you conduct on Life-XL

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DNA tests

This is about knowing what letters ("nucleotides") your DNA is made of. This is not a measure of health. However, we propose such tests here because some health tests we suggest come with of such tests, and because of the natural interest in discovering what we are made of, if we have genetic factors that correlate with some diseases or with longevity, or where we come from.
DNA health profile - by Muhdo - £119.99 GBP
€ 200 EUR

 
Based on saliva. Of note, your "Biological age & epigenetic profile" contains your "DNA health profile" and provides information that are more health-related than the sequence of your DNA.

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Precise DNA test - by Dayu - €599 EUR
€ 599 EUR

 
This is a whole-genome-sequencing of good accuracy. Most commercialized DNA tests, like 23andme, measure "SNIPs": specific letters of the DNA; whole genome sequencing measures almost all letters. Most commercialized DNA tests are of precision "1x", a good precision would be "50X", as it averages the result over 50 measures of DNA (each having noise, notably DNA mutations during the preparation process). This test is "30X", with relatively few errors.

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Highly precise DNA test - by Dayu - €899 EUR
€ 899 EUR

 
There is a test at "130X". It includes the "30X" test.

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Diagnostics suggested by visitors of TIMExtension

Warning: these diagnostics have not been discussed with the scientific board of TIMExtension. While we will try to remove inadequate content, we decline any responsibilty with regards to these diagnostics suggested by visitors.

 
 

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